What are the Possibilities of Antibiotics in Acute Pneumonia-Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS INTERNATIONAL JOURNAL OF PULMONARY & RESPIRATORY SCIENCES
Modern ideas about the nature of acute pneumonia (АР)
are the main obstacle to its successful treatment. On the one hand, AP
is not considered a contagious infectious disease, does not require
isolation of patients and the observance of special precautions, and the
known and widespread today pathogens of AP belong to representatives of
symbiotic microflora of healthy people.
On the other hand, all hopes for the successful
treatment of the disease are pinned only on antimicrobial effects.
“Antibiotics alone” is the initial treatment of all patients with AP.
The emergence of more and more antibiotic resistant strains of
microorganisms is a natural consequence of long-term and intensive use
of such treatment. Adaptability of microorganisms as representatives of
the biological world is their essential feature.
The ongoing process of confrontation between the
natural presence of microbes in many areas of our body and the means of
its suppression is endless and dynamic. At the same time, the
development and production of new more effective antibacterial drugs is a
constantly catching up party in this confrontation.The dream of a
universal antimicrobial agent and the eradication of
antibiotic-resistant strains is nothing more than a utopia.
If the rate of development of the inflammatory
process in the lungs does not exceed the compensatory ability of the
body, then the suppression of pathogens with antibiotics is sufficient
for recovery. With the more intensive development of the process, the
patient’s body does not have time to adapt to pathogenetic shifts, and
the process continues to develop even in spite of effective antibiotic
therapy. The result of the latter is a “sterile” pleural empyema, which
has been increasingly observed in recent years.
The presence of a serious problem becomes apparent
in cases where the initial treatment does not reach the goal and
progressive deterioration of the condition of patients requires
hospitalization. Modern medicine, even in a perfect supply cannot
guarantee a quick and successful recovery from АP. The results of АP
treatment in developed countries are not much better than those in
developing regions.
One-sided and narrowly focused interpretation of
the nature of the disease does not even imply the need for other types
of first aid. The way out of this deadlock is possible only after the
revision of the whole doctrine of the disease and justification of
pathogenetic approaches to treatment. The pilot stage of such a project
was implemented in 1976-1985 in Novokuznetsk state Institute for
advanced training of doctors (USSR, Russia). The basis of the new
doctrine of АP were already known and scientifically based medical
axioms. Following private studies were additionally performed:
a. Experimental model of AP (4 series of
experiments, 44 animals) obtaining a model of pleural complications
(certificate for invention No 1631574, A1,1 November 1990,USSR).
b. X-ray examination 56 lung anatomical preparations with different forms of the AP,taken from the dead patients.
c. Record comparative rheopulmonography before and after performing medical procedures(36 patients).
d. Analysis of the observation and treatment of 994 children with AP and its various destructive and pleural complications.
The revised treatment guidelines were applied in 101
patients in the initial period of aggressive forms of АP. The received
results allow to speak about possibility of the guaranteed prevention of
suppurative and destructive complications of the disease. The results
of this work were first published in Russian [1]. A list of publications
on the subject in English is provided below [2].
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